Analysis of 5 patients with acute glyphosate poisoning clinical characteristics and metabolic concentration
10.3760/cma.j.cn121094-20230823-00042
- VernacularTitle:急性草甘膦中毒患者临床特征及其毒物代谢浓度分析5例
- Author:
Jianrui DOU
1
;
Yan YANG
;
Hao ZHANG
;
Feng ZHANG
;
Yi ZHAO
;
Runfeng MIAO
Author Information
1. 扬州市疾病预防控制中心职业健康科，扬州 225001
- Keywords:
Glyphosate;
Aminomethyl phosphonic acid;
Poisoning;
Metabolic concentration;
HPLC-MS-MS
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(8):608-612
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between changes in the concentration of glyphosate (GLY) and its metabolites (AMPA) in patients with acute glyphosate poisoning and clinical symptoms, and to provide reference for the study of glyphosate toxicity.Methods:Urine samples from 5 patients with oral glyphosate poisoning admitted to the Emergency Department of Yangzhou Third Class A General Hospital from February to July 2021 were collected. Urine concentrations of GLY and AMPA were measured using derivatization gas chromatography-mass spectrometry, and analyzed based on the patient's clinical manifestations and treatment process.Results:The main symptoms of the patient after poisoning were acute gastrointestinal symptoms, such as nausea, vomiting, abdominal pain, etc. The concentration of GLY in the patient's urine reached its maximum on the first day and gradually decreased over time. On the day of discharge, the final concentration of GLY was 10% lower than the initial concentration. At discharge, the clearance rates of GLY in cases 1, 2, 3, and 4 were 96.97%, 95.91%, 96.87% and 92.87%, respectively.Conclusion:The glyphosate has a shorter maintenance time after entering the human body; There is no correlation between the concentration of glyphosate and its metabolites admitted to the hospital, the dose of poisoning, and clinical symptoms in poisoned patients.
