Clinical Observation of Duhuo Bugu Decoction Combined with Zoledronic Acid in the Treatment of Malignant Bone Metastasis
10.14148/j.issn.1672-0482.2017.0133
- VernacularTitle:独活补骨方联合唑来膦酸治疗恶性肿瘤骨转移的临床观察
- Author:
Ping BAI
1
;
Jiao-Jiao CHEN
;
Ling-Jing HU
;
Guo-Duo ZHANG
Author Information
1. 重庆市中医院肿瘤科
- Keywords:
malignant tumor;
bone metastasis;
Duhuo Bugu Decoction;
zoledronic acid
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the clinical effects of the combination of Duhuo Bugu decoction and zoledronic acid in the treatment of malignant bone metastasis.METHODS Fifty patients with bone metastases of malignant tumor were selected from the Department of oncology,Chongqing Hospital of traditional Chinese medicine from September 2014 to February 2016, and were randomly divided into the observation group and the control group.Two groups were both treated by zoledronic acid, and the observation group was also treated by adding Duhuo Bugu Decoction.Changes of the analgesic effects,analgesic dosa-ges and life quality scores(KPS)of two groups were observed before and after treatment.Urinary type I collagen amino termi-nal peptide(uNTX)and bone alkaline phosphatase(BALP)were measured via ELISA method before and after treatment.RE-SULTS Compared with the control group,the analgesic medicinal amount of the observation group reduced significantly(P<0.05),and KPS improved significantly(P<0.05).After the treatment,numerical pain scores(NRS) of two groups had no significant changes(P>0.05).After the treatment,uNTX and sBALP level of the treatment group decreased compared with that before treatment(P<0.01).While compared with the control group,the difference was not significant(P>0.05).CON-CLUSION The combination of Chinese herbs and zoledronic acid is an effective therapy for bone metastasis malignant tumors. Chinese herbs can effectively improve the analgesic effect,reduce the analgesic medicinal amount,improve the patients'life quality,and have a tendency of synergy in improving the bone destruction caused by tumor.
