Relationship Between Osteoclast-related Cytokines in Patients with Osteoporosis and TCM Syndromes
10.14148/j.issn.1672-0482.2017.0122
- VernacularTitle:骨质疏松症患者破骨细胞相关细胞因子与中医证型的关系
- Author:
Lei WANG
1
;
Zhi-Hui XIE
;
Chun-Sheng YUAN
;
Xiang-Bin GAO
;
Lin-Fang JIN
Author Information
1. 江南大学附属医院
- Keywords:
osteoporosis;
osteoclast cell;
TCM syndrome
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the correlation between the expression of osteoclast-related cytokines like MCSF, RANKL,TNFαIL1αin patients with osteoporosis and TCM syndromes.METHODS 120 cases with osteoporosis were divided into the kidney yang deficiency group(30 cases),deficiency of spleen and stomach group(30 cases),liver-kidney yin deficiency group(30 cases) and qi stagnation and blood stasis group(30 cases) based on syndrome differentiation.Fasting blood samples early in morning were collected and the expression of four items including MCSF,RANKL,TNF and IL1αwere tested by ap-plying euzymelinked immunosorbent assay method.RESULTS Kidney yang deficiency group experienced evident lower ex-pression of MCSF and RANKL than the other three groups,with significantly statistical differences,while no differences were noticed in the expression of TNFαand IL1αamong the four groups.CONCLUSION Detection of MCSF and RANKL expression can be considered as an effective way to distinguish the kidney yang deficiency syndrome from the other three types.Hence,we believe that there exists quantified obj ective evidence for osteoporosis syndrome differentiation in TCM.
