Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy.
- Author:
Yhun Yhong SHEEN
1
;
Min Jin KIM
;
Sang A PARK
;
So Yeon PARK
;
Jeong Seok NAM
Author Information
1. College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea. yysheen@ewha.ac.kr
- Publication Type:Review
- Keywords:
Transforming growth factor-beta (TGF-beta);
EW-7197;
ALK5;
Breast cancer;
Metastasis
- MeSH:
Breast Neoplasms;
Neoplasm Metastasis;
Transforming Growth Factor beta
- From:Biomolecules & Therapeutics
2013;21(5):323-331
- CountryRepublic of Korea
- Language:English
-
Abstract:
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-beta related functional contexts. This review discusses the molecular mechanism of the TGF-beta pathway and describes the different ways of tumor suppression and promotion by TGF-beta. In the last part of the review, the data on targeting TGF-beta pathway for cancer treatment is assessed. The TGF-beta inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
