Clinical Research of Shuangxin Decoction on Coronary Heart Disease Accompanied with Psychological Disorder
10.14148/j.issn.1672-0482.2017.0026
- VernacularTitle:双心汤干预冠心病合并心理障碍的临床研究
- Author:
Wei-Bing NI
1
;
Zu-Pei YAO
;
Fang-Qing GE
;
Xiao-Dan ZHENG
;
Juan CAI
;
Jin-Xiang PENG
;
Hai-Yan SU
Author Information
1. 南通市中医院心血管病科
- Keywords:
Shuangxin Decoction;
coronary heart disease;
chest pain and distress;
psychological disorder;
depression;
anxi-ety
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2017;33(1):26-29
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the clinical effects of Shuangxin Decoction in treating coronary heart disease accompa-nied with psychological disorder.METHODS 80 cases with coronary heart disease manifested as chest pain,chest distress plus psychological disorders like depression and anxiety were randomly divided into treatment group and control group.Patients in both groups were treated with routine western medicine plus psychological counseling.Based on which,patients in the treat-ment group were further given Chinese medicine Shuangxin Decoction,while those in the control group were added deanxit, with the course lasting for 6 weeks.Chest pain(distress) integral score scale,traditional Chinese medicine(TCM) syndrome score scale and comprehensive hospital anxiety and depression scale were evaluated to explore the therapeutic effects of chest pain,psychological disorder and clinical TCM syndromes before and after treatment of both groups,together with the changes of electrocardiogram test results and cardiac markers.RESULT Chest pain(distress) integral scores of treatment group were lower than those of control group(P <0.05),with the total curative rate being 82.50%,notably higher than 52.5% of the control group(P <0.01).The anxiety and depression scores of both groups were evidently reduced after treatment(P <0.01). The comparison of the two groups was P >0.05.TCM syndrome scores of both groups were notably declined(P <0.01).The total curative rate was 75%,which was superior to 20% of the control group(P <0.01).Both electrocardiogram test results and cardiac markers in both groups experienced an evident improvement than before(P <0.05).The comparison of the two groups showed P >0.05.No abnormality was detected in blood,urine,stool or liver and kidney function test in patients of both groups.CONCLUSION Shuangxin Decoction can efficiently improve chest pain,chest distress symptoms as well as TCM clinical syndromes due to coronary heart disease accompanied with psychological disorder.Also,it is helpful for improving de-pression and anxiety,which has been considered as a safe and effective formula for treating these two disorders,worthy of clin-ical application and promotion.
