Clinical effect observation of esomeprazole combined with pantoprazole injection on the treatment of patients with peptic ulcer complicated with gastric hemorrhage
10.7619/jcmp.201803031
- VernacularTitle:埃索美拉唑联合泮托拉唑针剂治疗消化性溃疡并发胃出血的临床疗效观察
- Author:
Xuetao DONG
1
;
Yandi LIU
Author Information
1. 天津市人民医院消化内科
- Keywords:
esomeprazole;
pantoprazole injection;
peptic ulcer;
gastric bleeding
- From:
Journal of Clinical Medicine in Practice
2018;22(3):109-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze clinical efficacy of esomeprazole combined with pantoprazole injection in the treatment of patients with peptic ulcer complicated with gastric hemorrhage.Methods Totally 150 patients with peptic ulcer complicated with gastric hemorrhage were randomly divided into control group and study group,75 cases in each group.The control group was treated with esomeprazole,and the study group was treated with esomeprazole combined with pantoprazole injection.The degree of pain,quality of life,amount of bleeding and curative effect were observed and compared between the two groups.Results After treatment,VAS score in both groups decreased significantly,and the VAS score of study group was significantly lower than the control group (P ＜0.05).After treatment,the SF-36 score in both groups increased significantly,and the SF-36 score in study group was significantly higher than the control group (P ＜ 0.05).In the study group,the total effective rate of study group was 97.3％,which was significantly higher than 82.7％ in the control group (P ＜0.05).Conclusion Esomeprazole combined with pantoprazole injection can effectively inhibit gastric acid secretion,protect the gastric mucosa alleviate lower abdominal pain.
