Research progress on pathogenesis of malignant mesothelioma

VernacularTitle:恶性间皮瘤发病机制研究进展
Author: Wen MEI ¹ ; Yepin ZHANG ; Shengjie YANG
Author Information

1. 楚雄彝族自治州人民医院病理科，楚雄　675000
Keywords: Mesothelioma; Malignant pleural mesothelioma (MPM); Pathogenesis; Asbestos
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2024;42(3):232-240
CountryChina
Language:Chinese
Abstract: The occurrence of malignant mesothelioma is related to exposure of asbestos. And many researchers have conducted in-depth analysis of the molecular changes of mesothelioma, showed that its molecular characteristics were chromosome changes, including chromosome rearrangement, gene mutation and gene deletion. Recent studies have strengthened our understanding of molecular characterization of mesothelioma, such as targeted mutations of tumor suppressor genes, differential gene expression, changes of miRNA and signal pathways. It is of great significance for the early diagnosis, clinical treatment and prognosis of malignant mesothelioma to explore the pathogenesis and development of malignant mesothelioma. This article reviews the research progress on the pathogenesis and carcinogenesis-related molecules of malignant mesothelioma.