Research progress on the mechanism of pyroptosis in airway epithelial barrier injury in asthma
10.3760/cma.j.cn121094-20220711-00364
- VernacularTitle:细胞焦亡在哮喘气道上皮屏障损伤中的作用机制研究进展
- Author:
Jinxia WANG
1
;
Fengfeng LEI
Author Information
1. 甘肃中医药大学第一临床医学院，兰州 730000
- Keywords:
Asthma;
Pyroptosis;
Airway epithelial barrier;
Injury
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(3):218-223
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a novel form of programmed cell death mediated by cleavage of Gasdermin family proteins by activated caspases, which plays an important role in the control of acute and chronic diseases. Asthma is a chronic inflammatory airway disease with varying degrees of airflow obstruction. The airway epithelial barrier plays an important role in initiating host defenses and controlling immune responses. Accumulating evidence suggests that pyroptosis is involved in the impairment of airway epithelial barrier function and abnormal immune regulation in asthma. This article aims to review the latest regulatory mechanism of pyroptosis involved in airway epithelial barrier injury in asthma under various environmental exposure factors, and to provide a new method for targeted therapy of asthma.
