Effect of Paeoniflorin on Hippocamp Tissue Pathomorphology and BDNF Level of Forced Swimming Rats Model

VernacularTitle:芍药苷对抑郁大鼠海马组织形态及 BDNF 水平的影响
Author: Mei XUE ¹ ; Dao-Zhou MU ; Xi HUANG
Author Information

1. 南京中医药大学共病郁证研究所
Keywords: Paeoniflorin; depression; hippocampus; BDNF
From: Journal of Nanjing University of Traditional Chinese Medicine 2016;32(5):439-441
CountryChina
Language:Chinese
Abstract: ABSTRACT:OBJECTIVE To observe the antidepressant effect of Paeoniflorin and the possible mechanism in acute depressed rat model of forced swimming.METHODS SD rats were randomly divided into control group,model group,peony glycoside group and fluoxetine group(10∕group).The model group,Paeoniflorin group and Fluoxetine group were forced to swim for 1 5 min to establish the depressed model.Treatment groups were administered paeoniflorin(10 mg∕kg) and fluoxetine (20 mg∕kg),respectively,3 times in 24 h.Control group were treated with vehicle(saline).Observation indexes:the opening experi-ment of behavior,levels of BDNF in serum and hippocampus and the pathological observation of hippocampus.RESULTS Paeoniflorin significantly increased the motility distance of rats(P <0.01)and BDNF levels in rat serum and hippocampus(P <0.01),which displayed protective effects on hippocampus pathomorphology.CONCLUSION Paeoniflorin shows antidepres-sant effect in forced swimming animal model,which probably relates to the BDNF∕TrkB receptor signal transduction pathway.