Expressions of brain natriuretic peptide, fibrinogen,hypersensitive C-reactive protein, D-Dimer and arterial blood gas analysis in acute exacerbation of chronic obstructive pulmonary disease patients complicated with pulmonary hypertension
10.7619/jcmp.201803008
- VernacularTitle:B型脑钠肽、超敏C反应蛋白、纤维蛋白原、D-二聚体及血气分析在慢性阻塞性肺疾病急性加重期合并肺动脉高压患者中的表达
- Author:
Hongli WU
1
;
Ruixue TIAN
;
Qing YE
;
Yujia SONG
Author Information
1. 北京市海淀医院呼吸科
- Keywords:
chronic obstructive pulmonary disease;
pulmonary hypertension;
brain natriuretic peptide;
fibrinogen;
hypersensitive C-reactive protein;
D-Dimer
- From:
Journal of Clinical Medicine in Practice
2018;22(3):31-33,37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions and significance of brain natriuretic peptide (BNP),hypersensitive C-reactive protein (hs-CRP),human fibrinogen (Fib),D-Dimer and blood gas analysis in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and pulmonary hypertension (PH).Methods Totally 135 patients with AECOPD were divided into single AECOPD group (n =75) and AECOPD + PH group (n =60).The value of pulmonary systolic pressure (PASP) was measured by echocardiography.Serum BNP,hs-CRP,D-Dimer,Fib levels and arterial blood gas analysis indexes such as p(CO2) and p(O2) were compared between two groups.Results The levels of hs-CRP,BNP,D-Dimer and p(CO2) in AECOPD + PH group were significantly higher than those in AECOPD group (P ＜ 0.05),while p (O2) in AECOPD + PH group was significantly lower than that in AECOPD group.Multiple linear regression analysis showed that the levels of hs-CRP,Fib,BNP,D-Dimer and p (CO2) were positively correlated with pulmonary artery pressure (P ＜ O.05),and p (02) was negatively correlated with PASP (P ＜ 0.05).Conclusion The hs-CRP,Fib,BNP,and D-Dimer participate in the formation of AECOPD complicated with pulmonary hypertension,and systemic inflammation plays an important role in the pathogenesis of AECOPD complicated with pulmonary hypertension.
