Correlation analysis of urinary arsenic species and health effect indicators of occupational arsenic exposure workers
10.3760/cma.j.cn121094-20230703-00228
- VernacularTitle:职业性砷接触工人尿形态砷含量与健康效应指标的相关性分析
- Author:
Wei QIU
1
;
Xin CHOU
;
Yue SHEN
;
Kunpeng MA
;
Daoyuan SUN
;
Zhen MIN
Author Information
1. 云南省第三人民医院职业病科，昆明 650011
- Keywords:
Occupational exposure;
Arsenic methylation;
Inorganic arsenic;
Monomethyl arsonic;
Dimethyl arsinic;
Arsenic species
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2024;42(2):102-107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between urinary arsenic and health effects through the determination and analysis of urinary arsenic levels in occupational arsenic exposed workers.Methods:In November 2021, 95 workers exposed to arsenic and its inorganic compounds and 31 administrative personnel from a non-ferrous metal smelter in Yunnan Province were selected as the contact group and control group, respectively. Urine forms of arsenic, blood tumor markers, liver function were detected, and micronucleus test was used to analyze the chromosome damage. The correlation between urine forms of arsenic and health effects were analyzed.Results:Compared with the control group, the concentrations of urinary trivalent inorganic arsenic (iAs 3+) , pentavalent inorganic arsenic (iAs 5+) , inorganic arsenic (iAs=∑iAs 3++iAs 5+) , monomethyl arsenic (MMA) , dimethyl arsenic (DMA) and urinary arsenic (∑iAs+MMA+DMA) at the end of class in contact group were higher ( P<0.05) . There was no statistically significant difference in blood tumor markers and liver function indicators between the two groups ( P>0.05) . Compared with the control group, the peripheral blood micronucleus rate and cell micronucleus rate in the contact group were significantly increased ( P<0.05) . The urinary arsenic, iAs 5+, inorganic arsenic and DMA were positively correlated with peripheral blood micronucleus rate in contact group ( rs=0.48, 0.34, 0.37, 0.23, P<0.05) , and the urinary arsenic, iAs 5+, DMA were positively correlated with peripheral blood micronucleus rate ( rs=0.48, 0.34, 0.26, P<0.05) . Conclusion:There is a significant correlation between different valence states of arsenic in the urine and abnormal health effects of occupational arsenic exposed workers. It is necessary to strengthen the detection of arsenic species in the urine of occupational arsenic exposed workers to better protect their health.
