Effects of Sijunzi Decoction on Immunologic Function and Quality of Life in Patients with Rectal Carcinoma After Surgery
10.14148/j.issn.1672-0482.2016.0334
- VernacularTitle:四君子汤对直肠癌术后免疫功能和生活质量的影响
- Author:
Shun YUE
1
Author Information
1. 淮安市第一人民医院肿瘤科
- Keywords:
Sijunzi Decoction;
rectal carcinoma;
immunologic function;
quality of life;
adjuvant chemotherapy
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2016;32(4):334-336
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the effects of Sijunzi Decoction on immunologic function and quality of life in patients with rectal carcinoma after surgery.METHODS 130 cases with rectal carcinoma having undergone surgery were randomly di-vided into study group(n =65) and control group(n =65).Patients in the control group were treated with FOLFOX7 chemo-therapy regimen,while those in the study group were further given Sijunzi Decoction,in addition to the FOLFOX7 chemother-apy regimen,with the treatment lasting for 4 courses.Then changes of KPS scores,Chinese medical syndrome scores and T-lymphocyte subsets were evaluated in both groups.RESULTS After treatment,KPS scores in the study group were increased evidently but decreased notably in the control group,and there were statistical significances between two groups in changes of quality of life(P <0.05).Compared to the study group,the decreased levels of CD3 + ,CD4 + ,CD8 + and CD4 +/CD8 + propor-tion in the control group after treatment were more obvious(P < 0.05 ~ 0.01).When compared to the control group,the symptom scores like anorexia,spiritlessness,abdominal distension,loose stool as well as the total scores went down more sig-nificantly in the study group(P <0.05~0.01).Pearson correlation analysis showed that KPS scores were positively related to CD4 +/CD8 + proportion(r =0.486,P <0.05),while TCM syndrome scores were negatively related to CD4 +/CD8 + propor-tion(r =-0.375,P <0.05).CONCULSION The adjuvant chemotherapy of Sijunzi Decoction plus FOLFOX7 regimen is ef-fective in treating postoperative rectal cancer by significantly improving the immunologic function,quality of life as well as the clinical symptoms.
