Investigation of serum surface active protein D and clara cell protein levels in workers exposed to silica dust in ferrous metal foundry
10.3760/cma.j.cn121094-20220606-00305
- VernacularTitle:黑色金属铸造企业接触矽尘工人血清表面活性蛋白D和克拉拉细胞蛋白水平调查
- Author:
Aihong WANG
1
;
Donghui DUAN
;
Xiaohai LI
;
Pengbo LENG
;
Yanyan LU
;
Dandan ZHANG
Author Information
1. 宁波市疾病预防控制中心环境与职业卫生所，浙江省微量有毒化学物健康风险评估技术研究重点实验室，宁波 315010
- Keywords:
Dust;
Ferrous metal casting;
Silicon dust;
Clara cell protein;
Surface active protein D
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2023;41(9):667-672
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the levels of serum surface active protein D (SP-D) and clara cell protein (CCl6) in workers exposed to black silica dust, and analyze its influencing factors.Methods:From July to September 2021, 174 workers in 37 positions exposed to silica dust in 5 ferrous metal foundry were investigated by cross-sectional research method. The exposure concentration of silica dust workers was obtained through occupational health field investigation and detection, and the general situation of the study subjects was obtained through questionnaire survey and peripheral blood was collected. Double antigen sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of SP-D and CC16 in serum of workers. The mean values were compared by one-way ANOVA, and the influencing factors of SP-D and CC16 concentrations in serum were analyzed by ordered multiple logistic regression.Results:The time-weighted average concentration (C-TWA) of 174 workers exposed to silica dust (respirable dust) ranged from 0.09 mg/m 3~3.58 mg/m 3, and the C-TWA overstandard rate of dust exposed workers was 32.18% (56/174) , with differences among workers in different positions (χ 2=28.85, P<0.001) . The highest concentration of silica dust was (0.82±0.11) mg/m 3. Using C-TWA<50% OEL occupational exposure limit (OEL) as reference, serum SP-D concentration in workers with ≥50% OEL was increased ( OR=4.95, 95% CI: 1.86~13.17, P=0.001) , while CC16 concentration was decreased ( OR=0.15, 95% CI: 0.05~0.40, P<0.001) ; Serum CC16 concentration decreased in workers exposed to silica dust C-TWA≥OEL ( OR=0.46, 95% CI: 0.28~0.98, P=0.043) . Compared with those with low occupational health literacy, the serum SP-D concentration of workers with high occupational health literacy decreased ( OR=0.48, 95% CI: 0.25~0.92, P=0.027) and CC16 concentration increased ( OR=2.09, 95% CI: 1.10-3.97, P=0.024) . Conclusion:When no abnormality was found in the physical examination of workers, the serum SP-D and CC16 concentration levels changed, and the change was related to the concentration of workers exposed to silica dust.
