A Case of Multiple Lentigines Syndrome.
- Author:
Shin Ae PAIK
;
Hong Il KOOK
- Publication Type:Original Article
- MeSH:
Cryotherapy;
Deafness;
Dermis;
Electrocardiography;
Electroencephalography;
Female;
Genitalia;
Gonads;
Humans;
Hypertelorism;
Lentigo;
LEOPARD Syndrome*;
Melanocytes;
Peas;
Pulmonary Valve Stenosis;
Skin;
Thorax;
Urinalysis;
Young Adult
- From:Korean Journal of Dermatology
1978;16(2):131-136
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple lentigines syndrome is characterized by the presence of numerous dark brown macules on the skin but not mucous surfaces and known also by the mnemvnic "LEOPARD syndrome" are, besides the lentigines, electrocardiographic conduction defect, ocular hypertelorism, pulmonary stenosis, abnormalities of the genitalia consisting of gonadal or ovarian hypoplasia, retardation of growth, deafness and inherited by autosomal dominant trait. We experienced a case of multipIe lentigine syrrdrome in 20-year old woman. She had numerous pinhead to pea sized, dark brownish macules on the entire body skin a,nd had no associated anomalies of other organ. On laboratory examinations including the CBC, urinalysis., chest X-ray, EKG; EEG, Hormone assay was all normal except for the slight anemic finding. On histologic examina,tion of biopsied macular skin showed a slight elongation of rete ri.dges, an increase in the concentration of melanocyte in the basal layer and mild inflammatory infiltration in the upper dermis. Treatment was done by cryotherapy on the face with marked improvement.
