Updates in the pathological diagnosis of Pleural Malignant Mesothelioma in the WHO classification of thoracic tumors (5 th edition)

VernacularTitle:《WHO胸部肿瘤分类（第五版）》中胸膜恶性间皮瘤病理学诊断的进展
Author: Zhenghua PIAO ¹ ; Xincheng ZHOU ; Xing ZHANG
Author Information

1. 宁波市临床病理诊断中心，病理科，宁波　315031
Keywords: Mesothelioma; Pleural malignant mesothelioma; 5 th WHO classification; Pathological diagnosis; Mesothelioma in situ; Histological grading
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2022;40(12):956-960
CountryChina
Language:Chinese
Abstract: The WHO Classification of Thoracic Tumors (5 th edition) mainly has the following changes in the chapter of pleural malignant mesothelioma. (1) The concept of mesothelioma in situ and its diagnostic method have been established for the first time; (2) The tumour grading of pleural malignant mesothelioma was added, it was divided into low grade and high grade according to the cellular atypia, mitotic activity and presence of necrosis. (3) The morphological features of pleural malignant mesothelioma was classified into architectural pattern, cellular and stromal features, the correlation between histological features and prognosis was refined, and some of the controversial cellular types have been reclassified. In this review, we introduced the changes of related pathologic diagnosis, in the WHO Classification of Thoracic Tumors (5 th edition) and discussed its clinical significance.