Effect of iron protein succinylate combined with erythropoietin on the prevention and treatment of anemia in high-risk premature infants
10.7619/jcmp.201723011
- VernacularTitle:蛋白琥珀酸铁联合促红细胞生成素防治高危早产儿贫血的效果观察
- Author:
Jinqi ZHANG
1
;
Xiaoying HUANG
;
Xiaoxuan SUN
Author Information
1. 东南大学附属中大医院儿科
- Keywords:
premature infants;
anemia;
iron protein succinylate;
erythropoietin
- From:
Journal of Clinical Medicine in Practice
2017;21(23):35-37,42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical value of iron protein succinylate combined with erythropoietin (EPO) on the prevention and treatment of anemia in high-risk premature infants.Methods The clinical data of 100 high-risk premature infants with anemia treated in our hospital were analyzed retrospectively,and were divided into combined group (iron protein succinylate combined with EPO,n =58) and control group (EPO,n =42) according to different medication methods.Changes of serum iron,serum ferritin (SF),hemoglobin (Hb),red blood cell count (RBC) and hematocrit (HCT) before and after treatment were compared between the two groups.The rate and times of blood transfusion in the two groups were statistically analyzed.The incidence rates of adverse reactions and anemia were compared between the two groups.Results After treatment,the serum iron,SF,Hb,RBC,HCT and body weight in the combined group,Hb,RBC,HCT and weight in the control group were increased (P ＜ 0.05),but the serum iron,SF,Hb,RBC,HCT and weight in the combined group were higher than those in the control group (P ＜ 0.05).The rate and times of blood transfusion and the incidence rates of anemia at different times in the combined group were lower than those in the control group (P ＜ 0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05).Conclusion Iron protein succinylate combined with EPO can effectively prevent anemia in high-risk premature infants,reduce the rate of blood transfusion and improve their hematopoietic function.
