Influence of Shenmai injection on cellular immune function of patients with severe acute pancreatitis
10.7619/jcmp.201723008
- VernacularTitle:参麦注射液对重症急性胰腺炎患者细胞免疫功能的影响
- Author:
Lingyan GU
1
;
Baisheng HU
;
Yixin WANG
Author Information
1. 上海市普陀区中心医院急诊外科
- Keywords:
Shenmai injuection;
severe acute pancreatitis (SAP);
immune function;
clinical effects
- From:
Journal of Clinical Medicine in Practice
2017;21(23):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively study the influence of Shenmai injection on clinical effects and cellular immune function of patients with severe acute pancreatitis (SAP).Methods A total of 70 patients with SAP in our hospital was retrospectively analyzed,and were randomly divided into observation group (traditional therapy and Shenmai injection) and control group (traditional therapy),with 35 cases per group.The general information,the clinical effects,acute physiology and chronic health evaluation Ⅱ scores (the APACHE Ⅱ scores),the immunity indicators (levels of NK T cells,CD4+ T cells,CD8+ T cells,CD4+/CD8+) before and after treatment,the adverse reaction rates in two groups were compared.Results The general information in two groups had no statistically significant difference (P ＞ 0.05).The disappearance of abdominal pain and distension,the time that returned to normal temperature,the first defection,normal levels of amylase in blood and urine,the length of stay in observation group were obviously shorter than that in the control group (P ＜ 0.05).The APACHE Ⅱ scores in two groups after treatment were obviously lower than treatment before,and the levels of immunity indicators after treatment were obviously higher than treatment before (P ＜ 0.05).After treatment,the APACHE Ⅱ score in observation group was obviously lower,and the immunity indicators in observation group were obviously higher than that in the control group (P ＜ 0.05).The adverse reaction rate in observation group was obviously lower than that in control group (5.9％ vs.27.3％,x2 =5.584,P =0.02).Conclusion Shenmai injection can improve the cellular immune function of SAP patients.
