Clinical Observation on Preventive Effect of Oxiliplatin Induced Peripheral Neuropathy by Fumigation of Siteng Yixian Decoction
10.14148/j.issn.1672?0482.2015.0420
- VernacularTitle:四藤一仙汤熏洗预防奥沙利铂所致周围神经毒性的临床观察
- Author:
Jingwen JIANG
1
;
Xuewu CHEN
;
Hongbing CAI
;
Lin WANG
;
Yingjin FU
;
Rongcheng LUO
Author Information
1. 海南省中医院肿瘤科
- Keywords:
Siteng Yixian decoction;
peripheral neuropathy;
oxaliplatininduced;
fumigation
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(5):420-423
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACTOBJECTIVE To observe the preventive effect of oxaliplatin induced peripheral neuropathy treated by fumigation of Siteng Yixian decoction.METHODS Totally 150 colorectal cancer patients from oncology department Of Hainan provincial hospital of TCM between January 2010 and December 2014 were enrolled in this study.And they were randomized into two groupswith 75 cases in each.The patients in the control group only received oxaliplatin based chemotherapy.While the pa-tients in the treatment group were given the chemotherapy combined with fumigation of Siteng Yixian decoction.The fumiga-tion lasted for forty minutes a timetwice a day.After the treatment of two cycles chemotherapythe incidence rate and sever-ity classification of peripheral neuropathy was analyzed one month later to evaluate the preventive effect.RESULTS The difference of incidence rate of peripheral neuropathy was significantwith the rate being 18.7% in the treatment group and 56. 0% in the control groupP <0.01.The severity classification was evidently higher in the control group90.37than those in the treatment group60.63and there exised a statistical significanceP <0.05.Among the patients who had second degree peripheral neuropathy or abovethe oxaliplatin accumulative dose was1 054.76±124.6in the treatment group and823.47 ±190.67 in the control groupand the difference was statistically significantP <0.05.Logistic regression indicated that fu-migation of Siteng Yixian decoction was the protective factor for the oxaliplatin?induced peripheral neuropathy.CONCLUSION Fumigation of Siteng Yixian decoction can reduce the incidence ratedecline the severity classification of oxaliplatin?induced peripheral neuropathy and increase the oxaliplatin tolerance dose.It is the independent preventive factor for oxaliplatin?induced peripheral neuropathy.
