Influence of Acupuncture on Plasma 5?HTNPY and CGRP in Patients with Constipation?predominant Irritable Bowel Syndrome
10.14148/j.issn.1672?0482.2015.0416
- VernacularTitle:针刺对便秘型肠易激综合征患者血浆5?HT、NPY 和CGRP 的影响
- Author:
Lixia PEI
1
;
Li ZHU
;
Lu CHEN
;
Xiaoliang WU
;
Junling ZHOU
;
Hao GENG
;
Jianhua SUN
Author Information
1. 南京中医药大学附属医院
- Keywords:
acupuncture;
IBS-C;
5-HT;
NPY;
CGRP
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(5):416-419
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACTOBJECTIVE To explore the acupuncture treatment mechanism of constipation?predominant irritable bowel syn-dromeIBS?C from the perspective of brain?gut axisby observing the plasma 5HTCGRP and NPY level before and after the treatment.METHODS 60 patients with IBS?C were randomly divided into two groups.30 cases in the acupuncture groupAG were treated by acupuncture five times a weekwith such acupoints as TianshuZusanliShangjuxuTaichongSanyin-jiaoYintangBaihui being selected.The other 30 cases in the medicine groupMGwere treated with lactulose oral solution15 ml per time for three times a day.After 4 weeks treatmentenzyme?linked immunosorbent assayELISAwas used to de-tect the plasma 5HTNPY and CGRP level of 30 healthy volunteers and the two treatment groups and observe the improve-ment of clinical symptoms.RESULTS ①Both groups could significantly improve the clinical symptoms in patients with IBS?CP <0.01while the curative effect in the AG was superior to that in the MGP <0.01.②The levels of 5?HTNPY and CGRP in patients with IBS?C of two treatment groups were significantly higher than those in healthy volunteersand the differ-ence was statistically significantP <0.01.The plasma 5?HTNPY and CGRP levels all went down in both groups after treatmentand the differences of 5?HTNPY and CGRP levels were significant when compared to the levels before treatment in AGP <0.01.The differences of 5?HTNPY levels were also significant when compared to the levels before treatment in MGP <0.01while there was no significant difference on CGRPP <0.01.There were no significant differences of 5?HT and NPY levels between these two groups after treatmentP >0.05but the difference of CGRP was highly statistically sig-nificantP <0.01.The downward trend of 5?HTNPY and CGRP level was better in the AG.CONCLUSION ①Acupunc-ture treatment can significantly improve the clinical symptoms in patients with IBS?Cand the theraputic effect is superior to that in the MG.②The increase of 5?HTNPY and CGRP level in patients with IBS?C after treatment suggests a close relation-ship between the abnormal level of brain?gut peptide and IBS syndrome.③Acupuncture treatment can decrease the plasma lev-els of 5?HTNPY and CGRPalleviate the degree of abdominal pain and discomfortwhich indicates that benign regulation of brain?gut peptide level in patients with IBS?C by acupuncture may be one of the effective mechanisms in treatmenting this dis-ease.
