Prognosis evaluation of prostaglandin E1 injected by different approaches in treating patients with acute non-ST segment elevation myocardial infarction by percutaneous coronary intervention in early stage
- VernacularTitle:不同途径注射前列腺素E1对急性非ST段抬高型心肌梗死行早期介入治疗术的预后评价
- Author:
Jun JI
1
;
Shenghu HE
;
Shu CHEN
;
Rixin XU
;
Xiaodong LIU
;
Qingchi LIAO
;
Bing XU
;
Jing ZHANG
;
Jianqiu ZHANG
Author Information
- Keywords: acute non-ST segment elevation myocardial infarction; percutaneous coronary intervention; corrected TIMI frame count; TIMI myocardial perfusion grade; prostaglandin E1
- From: Journal of Clinical Medicine in Practice 2017;21(23):4-7
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the clinical efficacy of prostaglandin E1 injected by coronary or peripheral venous in early stage (within 24 h of symptom onset) in treating patients with acute non-ST segment elevation myocardial infarction (NSTEMI) by percutaneous coronary intervention (PCI) and its influence on major adverse cardiac events (MACE).Methods A total of 136 patients with NSTEMI underwent PCI within 24 h were divided into intracoronary injection group,peripheral vein injection group and control group.All the patients were followed up for 9 months,no reflow or slow blood flow,the incidence of angina pectoris,heart failure,and target vessel revascularization,recurrent myocardial infarction and cardiac death and major cardiac adverse events during hospitalization were compared between three groups.The changes of left ventricular end diastolic diameter (LVDd),left ventricular ejection fraction (LVEF) and other indicators were compared.Results After PCI,the corrected TIMI frame count (CTFC) and TIMI myocardial perfusion grade (TMP) were significantly better in intracoronary injection group than peripheral vein injection group and control group (P ＜ 0.05).All patients were followed up for 9 months,LVDd in intracoronary injection group was significantly lower than those in peripheral vein injection group and control group (P ＜ 0.05).LVEF in intracoronary injection group was significantly higher than that in peripheral vein injection group and control group (P ＜ 0.05).The incidence rate of MACE in intracoronary injection group was significantly less than that in peripheral vein injection group and control group (P ＜ 0.05).There was no significantly difference between the peripheral vein injection group and control group (P ＞ 0.05).Conclusion For NSTEMI patients with early PCI,intracoronary injection and peripheral intravenous injection of prostaglandin E1 can get a better myocardial microcirculation reperfusion during operation,and intracoronary injection can significantly reduce the incidence of adverse cardiac events.
