Effects of Annaoning Granuleon Serum hs-CRP,IL-1βand MMP-9 in Patients with Hypertensive Intracerebral Hemorrhage
10.14148/j.issn.1672-0482.2015.0298
- VernacularTitle:安脑宁颗粒对高血压脑出血患者血清 hs-CRP、IL-1β、MMP-9的影响
- Author:
Cheng-Zhi YANG
1
;
Zhi-Gang WEI
Author Information
1. 徐州市中心医院神经内科
- Keywords:
Annaoning granule;
hypertensive intracerebral hemorrhage;
hypersensitive C-reactive protein;
interleukin-1β;
matrix metalloproteinase-9
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(3):298-300
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:OBJECTIVE To explore the effect of Annaoning granule on hypersensitive C-reactive protein(hs-CRP),inter-leukin-1β(IL-1β),and matrix metalloproteinase-9(MMP-9) in the serum of patients with hypertensive intracerebral hemor-rhage(HICH).METHODS 90 patients with HICH were randomly divided into 3 groups:the control group,the treatment group and the positive control group.The control group was given regular treatment with reducingintracranial pressure and taking hemostatic drug.The treatment group and the positive control group were given Annaoning granule and Ulinastatin re-spectively on the base of regular treatment.The blood samples of patients were collected before treatment and 3 days,7 days, 14 days after treatment.The serum hs-CRP was measured with immunoturbidimetry,the IL-1βwas measured with electro-chemiluminescence(ECLIA),and the MMP-9 was measured with enzyme linked immunosorbent assay(ELISA).The scores of Scandinavian Stroke Scale(SSS) were recorded in the three groups.RESULTS Compared with the control group,the serum levels of hs-CRP,IL-1β,MMP-9 in the treatment group and the positive control group were obviously decreased,and the SSS scores were increased on the 14th day(P <0.01~0.05).The comparison between the treatment group and the positive control group had no statistic significance(P >0.05).CONCLUSION Annaoning granule shows significant efficacy in treating HICH and advantage in cerebral protection.
