Effects of Three Kinds of Volatile Oils on Percutaneous Transport of Fluoxetine Hydrochloride in vitro
10.14148/j.issn.1672-0482.2015.0265
- VernacularTitle:积雪草等3种挥发油对盐酸氟西汀体外经皮渗透性的影响
- Author:
Sheng-Hui LI
1
;
Jia-Fu HUNG
;
Qing-Long DING
;
Qiang ZU
;
Jie LI
Author Information
1. 南京中医药大学药学院
- Keywords:
volatile oil of Centella asiatica;
volatile oil of Flos caryophylli;
volatile oil in Fols Magnolia;
fluoxetine hydro-chloride;
transdermic absorption
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(3):265-268
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:OBJECTIVE To study the effects of volatile oils,which were extracted from Centella asiatica,Flos caryophylli, Fols Magnolia,on the transdermal absorption of fluoxetine hydrochloride in vitro .METHODS Using modified Franz diffusion cell and excised male rat skin as transdermal barrier,the effect of volatile oils on permeation degree of fluoxetine hydrochloride from different concentration was compared with 3% azone and negative control group without penetration.The concentration of fluoxetine hydrochloride was determined by HPLC.Accumulative velocity constant and enhancing rate of fluoxetine hydrochlo-ride were calculated.RESULTS The penetration rates (J) of 10% volatile oil in Centella asiatica,3% volatile oil in Flos caryophylli,and 5% volatile oil in Fols Magnolia were 74.94,207.55,152.81 μg.cm-2.h-1/2 ,respectively,which were the largest among the different concentration of volatile oils.CONCLUSION The 10% volatile oil of centella asiatica,3% volatile oil in Flos caryophylli,5% volatile oil in Fols Magnolia could enhance penetration of fluoxetine hydrochloride obviously.
