Study of Electro-acupuncture on Phosphorylation of Tau Protein in Alzheimer's Disease Rats through p38MAPK Signaling Pathway
10.14148/j.issn.1672-0482.2015.0261
- VernacularTitle:电针调控 p38MAPK 通路降低 AD 大鼠海马磷酸化 tau蛋白表达的研究
- Author:
Min ZHANG
1
;
Gui-Hua XU
;
Wei-Xin WANG
;
Cai-Feng LUO
;
Rong-Zhu LU
;
Di-Juan MENG
Author Information
1. 南京中医药大学护理学院
- Keywords:
acupuncture;
Alzheimer's disease;
learning and memory abilities;
p38MAPK;
p-tau
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(3):261-264
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:OBJECTIVE To explore the mechanism of treating Alzheimer's disease model rats by electro-acupuncture through detecting the phosphorylation of p38MAPK and tau protein in hippocampus.METHODS SD rats were randomly di-vided into control group,sham-operated group,model group and electric-acupuncture group.The model group and electric-ac-upuncture group were injected with Aβ1-40 into hippocampus.20 d later,the electric-acupuncture group had electric-acupuncture at Baihui(GV20) and Shenshu(BL23)appoints.Morris Water Maze was used to observe rates memory abilities,and western blot and immunohistochemistry were used to determine the expression of p-p38MAPK and p-tau181.RESULTS The electric-acupuncture group significantly improved learning and memory abilities(P <0.05);expression of p-p38MAPK and p-tau181 in the model group was significantly higher than the others,while significantly reduced after electric-acupuncture treatment(P <0.05).CONCLUSION Acupuncture can regulate expression of p-tau181 through p38MAPK signaling pathway and improve the learning and memory ability of AD rats.
