Protective Effect of Shen Xi Capsule on Endotoxemia in Mice Heart
10.14148/j.issn.1672-0482.2015.0258
- VernacularTitle:参希胶囊对内毒素血症小鼠心脏的保护作用
- Author:
Ming-Hui ZHU
1
;
Li-Bing HUANG
;
Juan ZHU
;
Yu-Di ZHOU
;
Man ZHENG
Author Information
1. 南京中医药大学第一临床医学院
- Keywords:
endotoxemia;
myocardial injury;
inflammatory cytokines;
oxidative stress
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(3):258-260
- CountryChina
- Language:Chinese
-
Abstract:
ABSTRACT:OBJECTIVE To explore the protective effects of shenxi on heart in endotoxemic mice.METHODS The experi-mental mice were equally and randomly divided into control group,LPS group,shenxi group,shenxi+LPS group.The endo-toxemia model was established by intraperitoneally injecting LPS.Mice in groups shenxi and shenxi+LPS were intragastrically administered with shenxi solution(0.75 g/kg),while the same dose of normal saline were intragastrically administrated in con-trol group and LPS group.The heart function was detected with echocardiography,and TNF-α,IL-1β,MDA,SOD in myocar-dial tissue was estimated 6 hours after LPS administration.RESULTS Compared with control group,LPS treatment could re-sult in decreased myocardial activities of SOD,and elevated levels of TNF-α,IL-1β,MDA(P <0.05);shenxi treatment could improve the above aberrant indices.Compared with control group,LPS treatment could result in reduced cardiac function, while shenxi treatment could improve it.CONCLUSION Shenxi shows a good cardio-protective effect on the cardiac injury in endotoxemic mice,which may be reached by suppressing inflammatory infiltration and oxidative stress reaction.
