Preventive Effect of Evodiamin on Inflammation Associated Colorectal Cancer

VernacularTitle:吴茱萸碱对炎症相关性结直肠癌的预防作用研究
Author: Zhi-Ying TENG ¹ ; Xue-Ting CAI ; Yang YANG ; Gang CHEN ; Peng CAO
Author Information

1. 南京中医药大学药学院
Keywords: evodiamine; colorectum cancer; preventive effect
From: Journal of Nanjing University of Traditional Chinese Medicine 2015;(3):234-237
CountryChina
Language:Chinese
Abstract: ABSTRACT:OBJECTIVE To explore the preventive effect of evodiamine on inflammation associated colorectal carcinoma through the establishment of model in mice.METHODS The mice were administrated with AOM/DSS and divided into con-trol group,model group,low dose of evodiamine group(10EV)and high dose of evodiamine group(20EV).Body weights and death rates of mice were recorded once a week.The length of colorectum,tumor number and sizes were compared among all groups.Morphology of colorectal tissues in each group were stained by HE.Immunohistochemical analysis was used to detect the expression of COX-2 and PCNA.RESULTS AOM/DSS caused the loss of body weight and increased mortality of mice, while evodiamine improved the condition,and also reduced the development of colorectal cancer,alleviated the inflammatory response and inhibited abnormal proliferation of cancer cells.CONCLUSION Evodiamine can display promising preventive effects on inflammation-associated colorectal cancer,which is relative to the reduction of inflammation and abnormal cell prolif-eration.