The Choice of Preferred Materials of Ginkgolide Solid Dispersions
10.14148/j.issn.1672-0482.2015.0174
- VernacularTitle:银杏内酯固体分散体的辅料优选
- Author:
Ying MA
1
;
Zhi-Yang LYU
;
DILiu-qing
;
Jun-Song LI
;
GAn KAN
Author Information
1. 南京中医药大学药学院
- Keywords:
Ginkgolides;
solid dispersion;
dissolution rate;
optimization assistance materials
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(2):174-178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Choosing the optimizing assistance materials and the best proportional to make the solid dispersion of Ginkgolides,which so that can tremendously improve the dissolution rate of Ginkgolides.METHODS We determine the dissolution rate of the solid dispersion respectively,which are made by Eudragit EPO and PVP K30 in different drug-material ratio.In addition,quantitative phase determination of them are measured by DSC,X-RD and SEM.RESULTS The dissolu-tion rate of the solid dispersion with the Ginkgolides-EPO ratio in 1∶2,1∶4,1∶6,1∶8 were 65%,68%,70% and 71%respectively in five minutes.In the corresponding proportion,The dissolution rate of the solid dispersion made by PVP K30 were 40%,50%,66%,70% respectively.In the same time,the dissolution rate of the drug substance were 10%.Phase i-dentification results showed that Ginkgolides can evenly dispers in amorphous state in the solid dispersion.CONCLUSION The solid dispersion with the Ginkgolides-EPO ratio of 1∶2 is the best choice to preparation,which has the tremendous drug-loading and dissolution efficiency,thereby having a excellent prospect of application.
