Study the Effects of Qianyang Yuyin Granules on Renal Blood Flow and Blood Pressures in Anesthetized Normal Dogs

VernacularTitle:潜阳育阴颗粒对正常麻醉犬肾动脉血流量及血压的影响
Author: Heng-Wen SONG ¹ ; Le SHI ; Zhu-Yuan FANG ; Xuan-Xuan ZHU ; Fang-Fang ZHU ; Yang SHEN ; Tai-Lin ZENG ; Li XU
Author Information

1. 南京中医药大学药学院
Keywords: Qianyang Yuyin granules; anesthetized dogs; blood pressures; renal blood flow
From: Journal of Nanjing University of Traditional Chinese Medicine 2015;(2):143-146
CountryChina
Language:Chinese
Abstract: OBJECTIVE To study the effects of Qianyang Yuyin Granules(QYG)on blood pressure and renal blood flow in anesthetized normal dogs and the mechanism of hypertensive renal injury treatment.METHODS The renal blood flow,cardiac output(CO)and blood pressures were determined by PowerLab system at 15,30,60,90,120,180 min after QYG(3.08,6. 15,12.30 g/kg)administration,respectively.RESULTS Compared with the control group,QYG(12.30 g/kg)reduced sys-tolic blood pressure(SBP) significantly(P<0.05) at 120 min and 180 min,and increased the renal blood flow(P<0.05~0.01)at 90,180 min;QYG(6.15 g/kg)reduced SBP(P<0.05)at 120 min,and increased the renal blood flow(P<0.05) at 90,120 min.The effects of QYG(3.08 g/kg) were not obvious;The three QYG groups hardly affected CO (P>0.05). CONCLUSION QYG can increase the renal blood flow,improve the renal function and then reduce blood pressure.