The Anti-hyperglycemic Activity of Crude Polysaccharides from Mactra Veneriformis in Alloxan Induced Diabetes in Mice
10.14148/j.issn.1672-0482.2015.0134
- VernacularTitle:四角蛤蜊粗多糖对四氧嘧啶诱导I CR小鼠糖尿病模型的降血糖作用
- Author:
Wen-Nan DONG
1
;
Yao CHAI
;
Rui LIU
;
Jian-Ming CHENG
;
Hao WU
Author Information
1. 南京中医药大学江苏省海洋药用生物资源研究与开发重点实验室
- Keywords:
Mactra veneriformis;
crude polysaccharide;
hypoglycemic activity;
alloxan induced diabetic model
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2015;(2):134-137
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the anti-hyperglycemic effective sites of crude polysaccharides from Mactra veneriformis (MVPS).METHODS Hyperglycemia models were established by intravenous injection of alloxan via tail vein of ICR mice under a dose of 80 mg/kg.After 96 h,mice with fasting blood glucose levels≥11.1 mmol/L were chosen and divided into groups.MVPS 1 treated at the doses of 200,400,800 mg/kg and 1 200 mg/kg once daily,respectively.At 7th and 14th days, respectively,the levels of blood glucose,GSP,TCH and TG were measured.Other diabetic mice were divided into MVPS 1 (800 mg/kg),MVPS 2 (180,360 mg/kg) and MVPS 3 (2 040 mg/kg) groups.After 7 d treatment,both body weights and fasting blood glucose levels were measured.RESULTS MVPS 1 of 800 mg/kg displayed the optimal anti-hyperglycemic effect on diabetic mice and reduced GSP,TCH and TG levels of diabetic mice;MVPS 2 showed significantly anti-hyperglycemic ac-tivities,compared to the model group.MVPS 3 exhibited no anti-hyperglycemic activities.CONCLUSION MVPS 1 displays the optimal hypoglycemic effect at the dose of 800 mg/kg,and its hypoglycemic active site focuses on MVPS 2.
