Value of ischemic modified protein, microRNA-126 in diagnosis of posterior circulation transient ischemic attack and in prediction of secondary cerebral infraction
10.7619/jcmp.201721002
- VernacularTitle:缺血修饰蛋白、微小核苷酸-126对后循环短暂性脑缺血发作诊断及继发脑梗死的预测价值
- Author:
Zhanghong XIAO
1
;
Lidong DING
;
Huawu MAO
;
Xiaofang HANG
;
Xiaobo LU
;
Jing QIAN
;
Qi FANG
Author Information
1. 扬州大学附属泰州市第二人民医院神经内科
- Keywords:
ischemic modified albumin;
microRNA-126;
posterior circulation transient ischemic attack;
secondary cerebral infarction
- From:
Journal of Clinical Medicine in Practice
2017;21(21):6-11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ischemic modified albumin (IMA) and microRNA-126 (miR-126) in diagnosis of posterior circulation transient ischemic attack (PTIA) and in prediction of secondary cerebral infarction.Methods The clinical materials of 112 patients with PTIA were retrospectively analyzed.Serum IMA and miR-126 levels were measured at 3,6 and 12 h,and the correlation between serum IMA,miR-126 levels and PTIA as well as secondary cerebral infarction was analyzed by ABCD2 score.Results Serum IMA level was (54.19 ± 10.10) U/L in 80 healthy controls,and were (85.81 ±20.21),(62.98 ±12.79),(57.66 ±13.39) U/L at 3,6 and 12 h,respectively,in 112 patients with PTIA.and its levels of miR-126 at 6,12 h after PTIA attack were significantly decreased compared with (9.35 ± 1.76) in the healthy controls(P =0.036,P =0.001).In the patients with PTIA,the level of IMA at 3 h was negatively correlated with the level of miR-126 at 12 h (r =-0.3 13,P =0.0 00).When IMA and miR-12 6 levels were 6 7.5 2 U / L and 8.64,the sensitivity and specificity were 73.20,96.20,82.10,81.20,respectively.The followed up was lasted for 30 days in 112 patients with PTIA,and there were 11 cases (9.82％) with secondary cerebral infarction within 7 days,17 cases (15.18％) within 8 to 30 days.The relative risk rate of IMA level at 3 h and miR-126 level at 12 h in secondary ischemic stroke after PTIA were Rr =8.45,9.84;CI:1.10 to 65.03,1.13 to 86.02;P =0.040,0.039.Conclusion The early detection of IMA and miR-126 levels is of great value in diagnosis of PTIA and in prediction of secondary cerebral infarction.
