A Global Multiregional Proteomic Map of the Human Cerebral Cortex
- Author:
Guo ZHENGGUANG
1
;
Shao CHEN
;
Zhang YANG
;
Qiu WENYING
;
Li WENTING
;
Zhu WEIMIN
;
Yang QIAN
;
Huang YIN
;
Pan LILI
;
Dong YUEPAN
;
Sun HAIDAN
;
Xiao XIAOPING
;
Sun WEI
;
Ma CHAO
;
Zhang LIWEI
Author Information
1. Core Facility of Instrument,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China
- Keywords:
Brodmann area;
Proteomics;
Cerebral cortex;
Cingulate cortex;
Sensorimotor cortex
- From:
Genomics, Proteomics & Bioinformatics
2022;20(4):614-632
- CountryChina
- Language:Chinese
-
Abstract:
The Brodmann area(BA)-based map is one of the most widely used cortical maps for studies of human brain functions and in clinical practice;however,the molecular architecture of BAs remains unknown.The present study provided a global multiregional proteomic map of the human cerebral cortex by analyzing 29 BAs.These 29 BAs were grouped into 6 clusters based on similarities in proteomic patterns:the motor and sensory cluster,vision cluster,auditory and Broca's area cluster,Wernicke's area cluster,cingulate cortex cluster,and heterogeneous function cluster.We identified 474 cluster-specific and 134 BA-specific signature proteins whose functions are closely associated with specialized functions and disease vulnerability of the corresponding clus-ter or BA.The findings of the present study could provide explanations for the functional connec-tions between the anterior cingulate cortex and sensorimotor cortex and for anxiety-related function in the sensorimotor cortex.The brain transcriptome and proteome comparison indicates that they both could reflect the function of cerebral cortex,but show different characteristics.These pro-teomic data are publicly available at the Human Brain Proteome Atlas(www.brain-omics.com).Our results may enhance our understanding of the molecular basis of brain functions and provide an important resource to support human brain research.
