NORMA:The Network Makeup Artist-A Web Tool for Network Annotation Visualization
- Author:
Koutrouli MIKAELA
1
;
Karatzas EVANGELOS
;
Papanikolopoulou KATERINA
;
A.Pavlopoulos GEORGIOS
Author Information
1. Institute for Fundamental Biomedical Research,BSRC"Alexander Fleming",Vari 16672,Greece
- Keywords:
Network annotation;
Visualization;
Topological analysis;
Community detection;
Functional enrichment visualization
- From:
Genomics, Proteomics & Bioinformatics
2022;20(3):578-586
- CountryChina
- Language:Chinese
-
Abstract:
The Network Makeup Artist(NORMA)is a web tool for interactive network annotation visualization and topological analysis,able to handle multiple networks and annotations simultane-ously.Precalculated annotations(e.g.,Gene Ontology,Pathway enrichment,community detection,or clustering results)can be uploaded and visualized in a network,either as colored pie-chart nodes or as color-filled areas in a 2D/3D Venn-diagram-like style.In the case where no annotation exists,algorithms for automated community detection are offered.Users can adjust the network views using standard layout algorithms or allow NORMA to slightly modify them for visually better group separation.Once a network view is set,users can interactively select and highlight any group of interest in order to generate publication-ready figures.Briefly,with NORMA,users can encode three types of information simultaneously.These are 1)the network,2)the communities or anno-tations of interest,and 3)node categories or expression values.Finally,NORMA offers basic topo-logical analysis and direct topological comparison across any of the selected networks.
