Correlation between HLA-G gene polymorphism and gastric cancer in Han nationality
- VernacularTitle:汉族人HLA-G基因多态性与胃癌相关性研究
- Author:
Hongfu LIU
1
;
Lei ZHANG
;
Shuhua YANG
;
Xinhua ZHANG
;
Rongzhen XIE
;
Longying DENG
;
Wei DENG
Author Information
- Keywords: HLA-G; gene polymorphism; gastric cancer; correlation
- From: Journal of Clinical Medicine in Practice 2017;21(19):70-72
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the correlation between HLA-G gene polymorphism and gastric cancer in Han nationality.Methods A total of 123 gastric cancer patients in our hospital as the research objects (confirmed as gastric carcinoma by pathological diagnosis).At the same time,a total of 150 healthy controls were selected in our hospital,HLA-G and HLA-DRB1 allele subtypes were detected by polymerase chain reaction sequence specific primers (PCR SSP) detection method,and the allele distribution frequencies of subtypes of HLA-G and HLA-DRB1 were observed and analyzed.Results Compared with the control group,the observation group had higher detection rate in HLA-DRB1 * 03 and HLA-DRB1 * 15 (P ＜ 0.05),and RR were 1.427 and 2.209,respectively.And there were significant differences in HLA-G * 01012 distribution in two groups (P ＜ 0.05).Conclusion The incidence of gastric cancer may possibly correlated with HLA-G * 01012,HLA-DRB1-03 and HLA-DRB1-15 frequencies,and they are all protective genes.
