Effects of different hypoglycemic treatments on glucagon-like peptide-1 and its correlation with β cells function in newly diagnosed type 2 diabetes mellitus
10.7619/jcmp.201719016
- VernacularTitle:不同降糖方案对初诊2型糖尿病患者胰高血糖素样肽-1的影响及与β细胞功能的相关性
- Author:
Shufang MA
1
;
Zhipo DU
;
Yunxing WANG
;
Yuxiao WANG
;
Bingjie HOU
Author Information
1. 河北省唐县人民医院
- Keywords:
type 2 diabetes mellitus;
GLP-1;
insulin;
β cell function
- From:
Journal of Clinical Medicine in Practice
2017;21(19):56-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe different hypoglycemic treatments on glucagon-like peptide-1 (GLP-1) and its correlation with β cells function in newly diagnosed type 2 diabetes mellitus (T2DM).Methods A total of 76 patients with newly diagnosed T2DM were randomly divided into insulin aspart 30 group and oral drugs group.OGTT test were measured at 0,30,120 min,the serum levels of GLP-1 and corresponding C peptide,and insulin levels were measured,HOMA insulin secretion and insulin resistance index were calculated.Then 30 healthy cases were as the control group,GLP-1 levels were analyzed,and the changes of the index were compared.Results At each time point,blood glucose and glucose area under the curve (AUCg) was significantly decreased (P ＜0.05).Insulin and C-peptide and the AUC (AUCins,AUCc-p) were increased (P ＜ 0.05).HOMA-IR was statistically decreased compared with pre-therapy (P ＜ 0.05),HOMA-IS and △INS30/G30,△ INS120/G120 were significantly increased (P ＜ 0.05).Compared with pre-therapy,GLP-1 levels and AUCglp (area under the curve GLP-1) were significantly increased (P ＜0.05),and reached the peak at 120 min,closed to secretion curve of the control group.Conclusion GLP-1 levels were lower than normal in newly diagnosed T2DM patients,and different hypoglycemic drugs makes GLP-1 levels increase.Insulin,C-peptide and AUCins,AUCc-p,HOMA-IS,HOMA-IR,etc.,suggest that β-cell function is restored and insulin resistance is reduced.
