Clinical comparative study on intravenous low dose recombinant tissue plasminogen activator in the treatment of transient ischemic attack
10.7619/jcmp.201719010
- VernacularTitle:静脉低剂量重组组织型纤溶酶原激活物治疗短暂性脑缺血发作的临床对照研究
- Author:
Yongling SHEN
1
;
Haibao ZHU
;
Yong LI
;
Xiaoyi SANG
;
Guanwen ZHANG
;
Limin QI
Author Information
1. 河北省承德市中心医院神经诊断科
- Keywords:
low dose;
recombinant tissue type plasminogen activator;
transient ischemic attack;
therapeutic effects
- From:
Journal of Clinical Medicine in Practice
2017;21(19):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study and analyze the therapeutic effects of intravenous low dose recombinant tissue plasminogen activator (rt-PA) in the treatment of transient ischemic attack (TIA).Methods A total of 86 TIA patients were selected as the research subjects and divided into observation group (intravenous low dose rt-PA thrombolysis treatment combined with aspirin antiplatelet therapy applied,41 cases) and the control group (single aspirin antiplatelet therapy applied,45 cases) according to the treatment methods.The plasma tissue plasminogen activator (t-PA),the plasminogen activator inhibitor-1 (PAI-1) on admission,at 1,3,7,14 d of the treatment were detected and compared.The control rates of TIA of the patients in the two groups were observed and compared.The patients in the two groups were followed up for 1 year,the ratios of transformation to acute cerebral infarction in the two groups were observed and compared.Results At 1,3 d of the treatment,the plasma t-PA levels of the patients in the observation group were significantly higher than that in the control group,and the differences between the two groups were statistically significant (P ＜ 0.05).At every time points before and after the treatment,the differences of the plasma PAI-1 levels between the two groups were not statistically significant (P ＞ 0.05).There were no statistically significant differences in control rates of TIA in each period of time between the patients in the two groups (P ＞ 0.0 5).During the period of following-up,there were 2 cases and 4 cases of patients with transformation to acute cerebral infarction in the observation group and the control group,respectively,and there was no significant differences in the ratios of transformation to acute cerebral infarction between the two groups (P ＞ 0.05).Conclusion The application of intravenous infusion of low dose of rt-PA for thrombolysis on the basis of the antiplatelet therapy of aspirin can increase the plasma t-PA level in early period of patients with TIA,help to reduce the risk of thrombosis,but has no obvious influences on the plasma PAI-1 levels,the clinical efficacy and the long-term prognosis.
