Clinical analysis of risk factors of fracture patients in CKD5D stage
10.7619/jcmp.201719001
- VernacularTitle:CKD5D患者骨折风险的相关因素分析
- Author:
Weiying LIU
1
;
Xueqiang XU
;
Buyun WU
;
Huijuan MAO
;
Changying XING
Author Information
1. 南京医科大学第一附属医院肾内科
- Keywords:
chronic kidney disease;
maintenance dialysis;
fracture;
bone density
- From:
Journal of Clinical Medicine in Practice
2017;21(19):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of fracture patients in CKD5D stage.Methods A total of 124 CKD5D patients according to suffering fracture or not in past or at present were divided into fracture group and non-fracture group.Clinical data of age,sex,height,body mass index(BMI),dialysis duration,dialysis patterns,body mass index(BMI),hypertension,diabetes mellitus (DM) history,drug taking history were recorded.Laboratory examinations included hemoglobin (Hb),hematocrit (Hct),serum creatinine (Scr),blood urea nitrogen (Bun),albumin (A),triglyceride (TG),cholesterol(TC),high-density lipoprotein (HDL),low density lipoprotein (LDL),serum sodium (Na +),serum calcium (Ca2 +),serum phosphorus (P),parathyroid hormone (PTH),alkaline phosphatase (AKP),and 25 (OH) VitD.And bone mass density (BMD) were measured.Results The fracture patients had longer dialysis duration,higher of hemodialysis ratio,higher serum Ca2 +,serum P,serum PTH and AKP,lower T and Z values of bone density than those patients without fracture.Univariate regression analysis of fracture risk suggested that dialysis age,high calcium,high phosphorus,high PTH,high AKP,high 25 (OH) VitD and fracture were positively correlated with peritoneal dialysis,and was negatively correlated with the use of calcium and peritoneal dialysis.The Multivariate regression analysis showed that high PTH,high AKP was positively correlated with fracture occurrence,lumbar vertebra bone density and the use of calcium were negatively correlated with fracture.Conclusion Low bone mineral density is an important risk factor for fracture.The use of calcium can reduce the risk of fracture.High PTH and high AKP should be actively intervened in CKD5D patients.
