Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women
- Author:
Zhang XIAOAI
1
;
Zhai QINGZHI
;
Wang JINFENG
;
Ma XIULING
;
Xing BO
;
Fan HANG
;
Gao ZHIYING
;
Zhao FANGQING
;
Liu WEI
Author Information
1. State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,China
- Keywords:
Chinese pregnant women;
Vaginal microbiota;
Postpartum;
Pregnancy complication;
Premature rupture of membranes;
Preterm birth
- From:
Genomics, Proteomics & Bioinformatics
2022;20(2):322-333
- CountryChina
- Language:Chinese
-
Abstract:
A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequenc-ing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lacto-bacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,dis-criminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)Ⅳ-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health.
