Factors affecting the recovery of cholinesterase activity in patients with acute chlorpyrifos poisoning
10.3760/cma.j.cn121094-20200619-00348
- VernacularTitle:急性毒死蜱中毒患者胆碱酯酶活力恢复的影响因素
- Author:
Minghao ZHANG
1
;
Shunzhong ZHAO
;
Xiaoxi TIAN
;
Guoqiang FU
;
Boliang WANG
Author Information
1. 710038 西安,空军军医大学第二附属医院急诊科
- Keywords:
Chlorpyrifos;
Posioning;
Hemoperfusion;
Cholinesterase;
Multivariate linear regression
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2021;39(4):286-288
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the related factors affecting the recovery of cholinesterase (ChE) activity in patients with acute chlorpyrifos poisoning.Methods:In February 2020, the clinical data of acute chlorpyrifos poisoning patients admitted in our hospital from January 2016 to December 2019 were retrospectively analyzed. The outcome variable was the time of ChE activity recovered to 50% lower limit of normal value, and multivariate linear regression analysis was performed to explore its influencing factors.Results:A total of 78 patients, 43 males and 35 females, with an average age (39.58±14.77) years were enrolled in this study. The average time of serum ChE activity recovered to 50% lower limit of normal value was (24.45±2.64) days. There was a correlation between hemoperfusion ( r=-0.644) , atropine dosage ( r=0.498) , chlorophosphorus dosage ( r=0.432) and the time of serum ChE activity recovered to 50% lower limit of normal value, in which hemoperfusion was significantly negatively correlated with the time of serum ChE activity recovered to 50% lower limit of normal value ( β=-4.222, P<0.05) . Conclusion:The recovery of serum ChE activity in patients with acute chlorpyrifos poisoning is very slow. Hemoperfusion can quickly remove chlorpyrifos, its metabolites and inflammatory mediators in the blood, thus effectively promoting the recovery of ChE activity.
