Risk factors of women with coronary heart disease in different postmenopausal periods and its clinical characteristics
10.7619/jcmp.201717023
- VernacularTitle:绝经不同时期女性冠心病的危险因素及临床特点分析
- Author:
Qianrong ZHANG
1
;
Yangjing LIANG
;
Suilong ZHANG
;
Minying ZHENG
Author Information
1. 西安交通大学第二附属医院
- Keywords:
coronary heart disease;
menopausal period;
estrogen levels
- From:
Journal of Clinical Medicine in Practice
2017;21(17):79-81,85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical characteristics and risk factors in early and advanced menopausal women with coronary heart disease (CHD).Methods A total of 259 menopausal women with CHD confirmed by coronary angiography in our hospital were selected as research objects,among whom 102 cases were in menopause≤ 10 years group,and 157 cases in menopause ＞ 10 years group.The clinical characteristics and risk factors of two groups were compared.Results The menopause ≤ 10 years group had higher incidence rate of hypertension and estrogen levels(P ＜ 0.05),but there was no significant difference in HLD-C,and TC levels,and carotid intima-media thickness (IMT) reached the degree of atherosclerosis.Menopause ＞ 10 years group showed a significantly higher incidence of diabetes,but LDL-C level and estrogen levels was significantly lower (P ＜ 0.05).The coronary artery disease in the menopause≤ 10 years group mainly occurred in single lesion,while the menopause ＞ 10 years group in double or multi-vessel lesion (P ＜0.05).Multivariate analysis showed that hypertension,diabetes,triglycerides,low-density lipoprotein cholesterol were risk factors for coronary heart disease,while estradiol was a protective factor.Conclusion Hypertension,diabetes,triglycerides,and low-density lipoprotein cholesterol and decreased estrogen are risk factors for women with coronary heart disease.Conditions of vascular endothelium and atherosclerosis of early postmenopausal women are better than the advanced postmenopausal women,and estrogen alternative is favorable for the patients.
