Correlation between macrophage inflammation protein-1α as well as tumor necrosis factor-α in gingival sulcus fluid and the condition of chronic periodontitis and its therapeutic efficacy
10.7619/jcmp.201717012
- VernacularTitle:龈沟液巨噬细胞炎症蛋白-1α及肿瘤坏死因子-α与慢性牙周炎病情及疗效的关系
- Author:
Huairong HUANG
1
;
Fanrong HU
Author Information
1. 福建省厦门市口腔医院
- Keywords:
macrophage inflammation protein-1 α;
tumor necrosis factor-α;
periodontitis;
curative effect
- From:
Journal of Clinical Medicine in Practice
2017;21(17):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between macrophage inflammation protein-1 α(MIP-1 α) as well as tumor necrosis factor-α(TNF-α) in gingival sulcus fluid and chronic periodontitis and its curative efficacy.Methods A total of 52 chronic periodontitis patients in our hospital were selected as experimental group and 30 healthy subjects were selected as control group.The experimental group received basic periodontal treatment (supragingival scaling and subgingival curettage) and oralhealth education while the control group was only given GI,BI,PG,AL examination without any treatment.The correlation between contents of MIP-1α as well as TNF-α in gingival sulcus fluid before and after treatment in two groups and the gingival indicators (GI),bleeding index (BI),and the depth of the probe (PD) were explored.Results Before treatment,the GI,BI and other clinical indicators of experimental group were higher than that in the control group (P ＜ 0.05).The GI,BI and other clinical indicators of effective patients in the experimental group were lower than that of the control group after treatment (P ＜ 0.05).MIP-1 α as well as TNF-α in gingival sulcus fluid were significantly correlated with clinical indicators (P ＜ 0.05).After treatment,the content of MIP-1 α as well as TNF-α in gingival crevicular fluid in the experimental group were lower than treatment before (P ＜ 0.05).Conclusion MIP-1 α as well as TNF-α in gingival crevicular fluid are correlated with periodontal clinical indicators.
