COVID-ONE-hi:The One-stop Database for COVID-19-specific Humoral Immunity and Clinical Parameters
- Author:
Xu ZHAOWEI
1
,
2
;
Li YANG
;
Lei QING
;
Huang LIKUN
;
Lai DAN-YUN
;
Guo SHU-JUAN
;
Jiang HE-WEI
;
Hou HONGYAN
;
Zheng YUN-XIAO
;
Wang XUE-NING
;
Wu JIAOXIANG
;
Ma MING-LIANG
;
Zhang BO
;
Chen HONG
;
Yu CAIZHENG
;
Xue JUN-BIAO
;
Zhang HAI-NAN
;
Qi HUAN
;
Yu SIQI
;
Lin MINGXI
;
Zhang YANDI
;
Lin XIAOSONG
;
Yao ZONGJIE
;
Sheng HUIMING
;
Sun ZIYONG
;
Wang FENG
;
Fan XIONGLIN
;
Tao SHENG-CE
Author Information
1. Shanghai Center for Systems Biomedicine,Key Laboratory of Systems Biomedicine(Ministry of Education),Shanghai Jiao Tong University,Shanghai 200240,China
2. Key Laboratory of Gastrointestinal Cancer(Fujian Medical University),Ministry of Education,School of Basic Medical Sciences,Fujian Medical University,Fuzhou 350122,China
- Keywords:
Protein microarray;
Humoral immunity;
One-stop tool;
Shiny
- From:
Genomics, Proteomics & Bioinformatics
2021;19(5):669-678
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus disease 2019(COVID-19),which is caused by SARS-CoV-2,varies with regard to symptoms and mortality rates among populations.Humoral immunity plays critical roles in SARS-CoV-2 infection and recovery from COVID-19.However,differences in immune responses and clinical features among COVID-19 patients remain largely unknown.Here,we report a database for COVID-19-specific IgG/IgM immune responses and clinical parameters(named COVID-ONE-hi).COVID-ONE-hi is based on the data that contain the IgG/IgM responses to 24 full-length/truncated proteins corresponding to 20 of 28 known SARS-CoV-2 proteins and 199 spike protein peptides against 2360 serum samples collected from 783 COVID-19 patients.In addition,96 clinical parameters for the 2360 serum samples and basic information for the 783 patients are integrated into the database.Furthermore,COVID-ONE-hi provides a dashboard for defining samples and a one-click analysis pipeline for a single group or paired groups.A set of samples of interest is easily defined by adjusting the scale bars of a variety of parameters.After the"START"button is clicked,one can readily obtain a comprehensive analysis report for further interpretation.COVID-ONE-hi is freely available at www.COVID-ONE.cn.
