Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model
- Author:
Chang YAFEI
1
;
Jiang YISHENG
;
Li CUI
;
Wang QIN
;
Zhang FENG
;
Qin CHENG-FENG
;
Wu QING-FENG
;
Li JING
;
Xu ZHIHENG
Author Information
1. Department of Bioinformatics and Biostatistics,School of Life Sciences and Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China
- Keywords:
Zika virus;
Brain development;
Microcephaly;
Gene network;
Signaling pathway
- From:
Genomics, Proteomics & Bioinformatics
2020;18(6):737-748
- CountryChina
- Language:Chinese
-
Abstract:
The association of Zika virus (ZIKV) infection with microcephaly has raised alarm worldwide. Their causal link has been confirmed in different animal models infected by ZIKV. However, the molecular mechanisms underlying ZIKV pathogenesis are far from clear. Hence, we performed global gene expression analysis of ZIKV-infected mouse brains to unveil the biolog-ical and molecular networks underpinning microcephaly. We found significant dysregulation of the sub-networks associated with brain development, immune response, cell death, microglial cell acti-vation, and autophagy amongst others. We provided detailed analysis of the related complicated gene networks and the links between them. Additionally, we analyzed the signaling pathways that were likely to be involved. This report provides systemic insights into not only the pathogenesis, but also a path to the development of prophylactic and therapeutic strategies against ZIKV infection.
