Experimental study of integrin αvβ3 micro positron emission tomography (microPET)/CT imaging with 68Ga-DOTA-RGD2 in diagnosis of breast cancer osteolytic bone metastases

VernacularTitle:整合素受体核素显像诊断乳腺癌骨转移病灶的实验研究
Author: Jun ZHAO ¹ ; Guoqiang SHAO ; Weihong XUE
Author Information

1. 江苏省常州市第二人民医院核医学科
Keywords: osteolytic lesion; breast carcinoma; bone metastasis; integrin
From: Journal of Clinical Medicine in Practice 2017;21(15):101-103
CountryChina
Language:Chinese
Abstract: Objective To explore the value of integrin αvβ3 micro positron emission tomography (microPET)/CT imaging with 68Ga-DOTA-RGD2 in diagnosis of breast cancer osteolytic bone metastases.Methods MDA-MB-231 was injected in left ventricle of hairless mice at the density of 1.0×10 7/mL.Animal model with parathyroid hormone(PTH)-induced osteolysis in the calvarium was established.Animals were randomly divided into RGD group (n=10) and FDG group (n=10), and were detected by 68Ga-DOTA-RGD2microPET/CT and 18F-NaFmicroPET/CT respectively.Animals were sacrificed and bone lesions were collected for pathological examination.Results Bone radiotracer uptake ratio of osteolytie lesion to normal calvrium (O/N) was (4.18±0.570) by 68Ga-DOTA-RGD2, which was significantly higher than (1.24±0.28) in group FDG by 18F-NaFmicroPET/CT imaging (P<0.05).Conclusion 68Ga-DOTA-RGD2 integrin receptor αvβ3 imaging can effectively detect breast cancer bone metastases and locate osteolytic lesions.