Research progress in pathogenesis of pneumoconiosis

VernacularTitle:细胞因子在尘肺发病机制中的研究进展
Author: Fanli JIN ¹ ; Lanxi ZHANG ; Kai CHEN ; Yange TIAN ; Jiansheng LI
Author Information

1. 450046　郑州，河南中医药大学，呼吸疾病中医药防治省部共建协同创新中心/河南省中医药防治呼吸病重点实验室；450046　郑州，河南中医药大学第一附属医院
Keywords: Cytokines; Pneumoconiosis; Mechanism; Occupational; Fibrosis
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2020;38(12):948-952
CountryChina
Language:Chinese
Abstract: Pneumoconiosis is an occupational lung disease that is mainly caused by diffuse fibrosis of lung tissue due to long-term inhalation of productive dust during occupational activities and retention in the lungs. Macrophages, epithelial cells and other cells can release a large number of cytokines, such as transforming growth factor-β, monocyte chemotactic protein-1, etc. These cytokines can participate in pathologies such as local injury, inflammatory response, and pulmonary fibrosis. This article reviews the role of cytokines in the pathogenesis of pneumoconiosis in order to provide a basis for further research.