Effect of metformin combined with Diane-35 on endocrine of patients with polycystic ovarian syndrome
10.7619/jcmp.201715026
- VernacularTitle:二甲双胍结合炔雌醇环丙孕酮片对多囊卵巢综合征妇女内分泌的影响
- Author:
Lu WANG
1
;
Yanru XU
;
Lihua DUAN
;
Liyan YAO
Author Information
1. 新疆医科大学第二附属医院 妇产科
- Keywords:
metformin;
Diane-35;
polycystic ovary syndrome;
luteinizing hormone;
insulin resistance
- From:
Journal of Clinical Medicine in Practice
2017;21(15):95-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe effect of effect of metformin combined with Diane-35 on endocrine of patients with polycystic ovarian syndrome (PCOS).Methods A total of 136 cases with PCOS in our hospital were randomly divided into observation group and control group, 68 cases in each group.The control group was treated with Diane-35 only, while the observation group was treated with Diane-35 and metformin.The overall effective rate, hormone indicators [luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (TEST), estrogen (E2), sex hormone binding globulin (SHBG)], and insulin resistance condition [homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment-β (HOMA-β)] were compared before and after treatment.Results The effective rate in the observation was obviously higher than that of the control group(97.1% vs.75.0%, P<0.01).The hormone related indicators (LH, FSH, TEST, E2, SHBG) of the observation group significantly improved after treatment (P<0.01).The hormone related indexes (LH, TEST, E2) of the control group significantly improved after treatment (P<0.01), and the observation group was significantly better than the control group (P<0.01).The HOMA-IR and HOMA-β in the observation group were obviously lower than treatment before (P<0.01), and were significantly lower than those of the control group (P<0.01).Conclusion Metformin combined with Diane-35 can significantly improve the endocrine disorder and insulin resistance, and improve overall effective rate.
