Long Non-coding RNA Derived from lncRNA–mRNA Co-expression Networks Modulates the Locust Phase Change
- Author:
Li TING
1
,
2
;
Chen BING
;
Yang PENGCHENG
;
Wang DEPIN
;
Du BAOZHEN
;
Kang LE
Author Information
1. Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China
2. CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Sciences,Beijing 100049,China
- Keywords:
Phenotypic plasticity;
Locusta migratoria;
Non-coding RNA;
Hub lncRNA;
Behavior
- From:
Genomics, Proteomics & Bioinformatics
2020;18(6):664-678
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) regulate various biological processes ranging from gene expression to animal behavior. Although protein-coding genes, microRNAs, and neuropep-tides play important roles in the regulation of phenotypic plasticity in migratory locust, empirical studies on the function of lncRNAs in this process remain limited. Here, we applied high-throughput RNA-seq to compare the expression patterns of lncRNAs and mRNAs in the time course of locust phase change. We found that lncRNAs responded more rapidly at the early stages of phase transition. Functional annotations demonstrated that early changed lncRNAs employed different pathways in isolation and crowding phases to cope with changes in the population density. Two overlapping hub lncRNA loci in the crowding and isolation networks were screened for func-tional verification. One of them, LNC1010057, was validated as a potential regulator of locust phase change. This work offers insights into the molecular mechanism underlying locust phase change and expands the scope of lncRNA functions in animal behavior.
