Correlation between gonadotropin-releasing hormone and cervical cancer
10.7619/jcmp.201715015
- VernacularTitle:促性腺激素释放激素和宫颈癌的相关性研究
- Author:
Fengyan LI
1
;
Zhiyan CHEN
;
Xiaocui LI
;
Yuanqiu MIAO
;
Chunjing LIU
Author Information
1. 河北省秦皇岛经济技术开发区医院
- Keywords:
gonadotropin-releasing hormone;
cervical cancer;
clinical stage;
expression
- From:
Journal of Clinical Medicine in Practice
2017;21(15):57-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of gonadotropin-releasing hormone (GnRH) in cervical cancer and to explore the correlation.Methods A total of 68 patients with cervical squamous cell carcinoma and 45 patients with chronic cervicitis were selected.Immunohistochemistry and hybridization in situ were used to detect the expression of GnRH in cancer tissue and cervicitis.Protein and nucleic acid level were observed in patients with GnRH.Results In 45 patients with cervicitis, both GnRH and GnRH mRNA expressions were negative in cervical epithelial tissue, while in 68 cases of cervical squamous cell cancer, the positive expression of GnRH in cancer tissues was 82.36%, and positive expression rate of GnRH mRNA was 64.71%.There were significant differences in levels of GnRH and GnRH mRNA between patients with cervicitis and cervical squamous cell carcinoma (P<0.05).The qualitative expression rates of GnRH in different clinical stages of cervical cancer were 55.56% of Ib, 87.10% of IIa and 100% of IIb, and qualitative expression rates of GnRH mRNA in different clinical stages of cervical cancer were 38.89% of Ib, 70.97% of IIa and 84.21% of IIb.There were significant differences in GnRH and GnRH mRNA levels between patients with different clinical stages of cervical cancer (P<0.05).Conclusion There is a high level of gonadotropin-releasing hormone in cervical cancer, which may be involved in the development of cancer cells.
