Dynamic changes of blood lactic acid and risk factors of death in children with severe sepsis
10.7619/jcmp.201715012
- VernacularTitle:重症儿童脓毒症患儿血乳酸动态变化特点及死亡危险因素分析
- Author:
Ruling YANG
1
;
Hongmei XU
;
Ping QU
Author Information
1. 重庆医科大学附属儿童医院 感染科
- Keywords:
severe sepsis in children;
blood lactic acid;
prognosis;
risk factors
- From:
Journal of Clinical Medicine in Practice
2017;21(15):45-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the dynamic changes of blood lactic acid and the risk factors of death in children with severe sepsis.Methods A total of 87 children with severe sepsis admitted in our hospital were selected as sepsis group, and the blood lactic acid levels were determined with blood gas analyzer on admission, and at 6, 12, 24 and 48 h after admission.A total of 60 healthy children were selected as control group at the same time, and the blood lactic acid levels were compared between two groups.The patients were divided into death group and survival group according to the prognosis.The risk factors of death were analyzed by univariate and multivariate Logistic regression analysis.Results The blood lactic acid level in the sepsis group was significantly higher than the control group on admission (P< 0.05).The blood lactic acid level was significantly higher in children with MODS than those without (P<0.05).The blood lactic acid level was significantly higher in the death group than the survival group on admission, and at 6, 12, 24 and 48 h after admission (P<0.05).The PCIS score, serum albumin levels, the incidence rate of MODS, number of organs affected by MODS, shock and usage of intravenous corticosteroids showed significant differences between the death group and the survival group (P<0.05).Logistic multivariate regression analysis showed that the independent risk factors for death in children included PCIS score, number of organs affected by MODS, shock, blood lactic acid level and albumin level.Conclusion Dynamic monitoring of blood lactic acid level is of great significance in the diagnosis of severe sepsis and the evaluation of prognosis.
