Kinase–substrate Edge Biomarkers Provide A More Accurate Prognostic Prediction in ER-negative Breast Cancer
- Author:
Sun YIDI
1
,
2
;
Li CHEN
;
Pang SHICHAO
;
Yao QIANLAN
;
Chen LUONAN
;
Li YIXUE
;
Zeng RONG
Author Information
1. CAS Key Laboratory of Systems Biology,CAS Center for Excellence in Molecular Cell Science,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China
2. University of Chinese Academy of Sciences,Shanghai 200031,China
- Keywords:
ER-negative breast cancer;
Edge biomarkers;
Kinase;
Substrate;
Prognostic prediction
- From:
Genomics, Proteomics & Bioinformatics
2020;18(5):525-538
- CountryChina
- Language:Chinese
-
Abstract:
The estrogen receptor (ER)-negative breast cancer subtype is aggressive with few treat-ment options available. To identify specific prognostic factors for ER-negative breast cancer, this study included 705,729 and 1034 breast invasive cancer patients from the Surveillance, Epidemiol-ogy, and End Results (SEER) and The Cancer Genome Atlas (TCGA) databases, respectively. To identify key differential kinase-substrate node and edge biomarkers between ER-negative and ER-positive breast cancer patients, we adopted a network-based method using correlation coefficients between molecular pairs in the kinase regulatory network. Integrated analysis of the clinical and molecular data revealed the significant prognostic power of kinase-substrate node and edge featuresfor both subtypes of breast cancer. Two promising kinase-substrate edge features, CSNK1A1-NFATC3 and SRC-OCLN, were identified for more accurate prognostic prediction in ER-negative breast cancer patients.
