Effect of mycophenolate mofetil combined with small dose of glucocorticoids on the serum ions and β2-GPI/ox-LDL of patients with IgA nephropathy
10.7619/jcmp.201715008
- VernacularTitle:吗替麦考酚酯联合小剂量糖皮质激素对IgA肾病患者血清离子及β2-糖蛋白I/氧化低密度脂蛋白复合物水平的影响
- Author:
Weitao XU
1
;
Jingqin LIU
;
Yongfang SHI
;
Cankun XU
Author Information
1. 山东省枣庄矿业集团中心医院 肾内科
- Keywords:
mycophenolate mofetil;
glucocorticoids;
IgA nephropathy;
serum ions;
β2-GPI/ox-LDL
- From:
Journal of Clinical Medicine in Practice
2017;21(15):29-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of mycophenolate mofetil combined with small dose of glucocorticoids on the serum ions and β2-GPI/ox-LDL of patients with IgA nephropathy.Methods A total of 68 patients with IgA nephropathy were randomly divided into two groups, 34 cases in each group.Control group was treated with small dose of glucocorticoid, while the study group was treated with mycophenolate mofetil on the basis of control group.Serum markers and adverse reactions were recorded during the treatment.Results After treatment, levels of serum phosphorus and β2-GPI/ox-LDL decreased significantly in both groups, levels of serum calcium increased significantly, Scr, BUN, CysC and 24 h urine protein decreased significantly, levels of serum TGF-β1, IL-4 decreased significantly, IFN-γ increased significantly, levels of serum VEGF, ET-1 and MMP-9 decreased significantly (P<0.05).Compared with the control group, levels of serum phosphorus and β2-GPI/ox-LDL in the study group were significantly lower, levels of blood calcium were significantly higher, levels of Scr, BUN, CysC and 24 h urine protein were significantly lower, levels of serum TGF-β1, IL-4 were significantly lower, IFN-γ were significantly higher, and levels of serum VEGF, ET-1 and MMP-9 were significantly lower (P<0.05).Conclusion Mycophenolate mofetil combined with small dose of glucocorticoids is effective in the treatment of patients with IgA nephropathy, and it can reduce the levels of serum ions and β2-GPI/ox-LDL.
