Association of Polymorphisms within the Serotonin Receptor Genes 5-HTR1A, 5-HTR1B, 5-HTR2A and 5-HTR2C and Migraine Susceptibility in a Turkish Population.
10.9758/cpn.2016.14.3.250
- Author:
Yavuz YÜCEL
1
;
Salih COŞKUN
;
Beyhan CENGIZ
;
Hasan H ÖZDEMIR
;
Ertuğrul UZAR
;
Abdullah ÇIM
;
M Akif CAMKURT
;
M Ufuk ALUCLU
Author Information
1. Department of Neurology, Dicle University, Medical Faculty, Diyarbakır, Turkey.
- Publication Type:Original Article
- Keywords:
Migraine disorders;
Single nucleotide polymorphism;
Receptor;
serotonin;
5-HT2C;
Genetic association studies;
Headache
- MeSH:
Alleles;
Genetic Association Studies;
Headache;
Headache Disorders;
Healthy Volunteers;
Humans;
Migraine Disorders*;
Polymorphism, Single Nucleotide;
Promoter Regions, Genetic;
Receptor, Serotonin, 5-HT2C;
Risk Factors;
Serotonin*
- From:Clinical Psychopharmacology and Neuroscience
2016;14(3):250-255
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. METHODS: We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The rs6295, rs1300060, rs1228814, rs6311, rs6313, rs6314, rs6318, rs3813929 (−759C/T) and rs518147 polymorphisms were analyzed in 135 patients with migraine and 139 healthy subjects, using a BioMark 96.96 dynamic array system. RESULTS: We found no difference in the frequency of the analyzed eight out of nine polymorpisms between migraine and control groups. However, a significant association was found between the rs3813929 polymorphism in the promoter region of 5-HTR2C gene and migraine. Also, the allele of rs3813929 was more common in the migraine group. CONCLUSION: This result suggests that the 5-HTR2C rs3813929 polymorphism can be a genetic risk factor for migraine in a Turkish population.
